Mycamine micafungin for injection, for intravenous use. Jan, 2020 mycamine micafungin sodium for intravenous infusion. Micafungin sodium is a semisynthetic lipopeptide 12 echinocandin synthesized by a chemical modification of a fermentation product of coleophoma empetri f11899. The following is the list of drugs found on the king guide to parenteral admixtures critical care admixtures wall chart.
Intravenous medicine administration is the administration of sterile preparations of medicines directly into a vein, via a peripheral or central line, for therapeutic reasons 2007. Micafungin mycamine, astellas is metabolized in the liver and excreted in an inactive form in the bile and urine. What conditions does micafungin solution, reconstituted recon soln treat. Micafungin intravenous route description and brand names. Midazolam versed yes midazolam versed yes midazolam versed. Trusley craig, kupiec thomas c, trissel lawrence a, year. Micafungin is a semisynthetic echinocandin derived from a natural product of the fungus coleophama empedri with potent antifungal activity. Iv compatibility ysite information is displayed on the first page of the search results. Sirolimus and nifedipine levels are increased by 20%.
There are currently no randomised studies comparing micafungin with standard antifungal therapy. Do not tube list for pharmaceuticals revised july 2015 1drug alteration 2expense 3flammable 4 product foaming 5short expadmin time 6ok to tube powder, but not the reconstituted product 7aerosol containers over 2. Safety and pharmacokinetics of repeatdose micafungin in. Treatment of candidemia, acute disseminated candidiasis, candida peritonitis and abscesses without. Micafungin trade name mycamine is an echinocandin antifungal drug used to treat and prevent invasive fungal infections including candidemia, abscesses and esophageal candidiasis. Candidemiaacute disseminated candidiasiscandidal peritonitis and abscesses. A savings club is a program with a required monthly or annual fee that gives you access to special pricing.
Micafungin intravenous route before using mayo clinic. To search compatibility information from the trissels 2 clinical pharmaceutics database by lawrence a. The efficacy of micafungin in the treatment of invasive aspergillosis ia has not yet been evaluated in randomised, controlled studies. If you are taking this medicine to treat an infection, tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. It is also used to prevent candida fungal infections in stem cell transplant patients. Also prevents candida infection in people undergoing stem cell transplant.
Prior to administration, have second practitioner independently check. Unchanged micafungin is the principal circulating compound in systemic circulation. Micafungin, like other cyclic lipopeptides, noncompetitively inhibits the fungal specific enzyme 1,3betadglucan synthase, an enzyme essential for fungal cell wall synthesis. Treatment of candidemia, acute disseminated candidiasis, candida peritonitis and abscesses in adult and pediatric patients 4 months of age and older see clinical studies 14. Detailed listing of the iv drug compatibility and stability updates applied to the king guide to parenteral admixtures over the last 12 years.
Ibm micromedex iv compatibility is a reliable resource for onthego access to the industrys most trusted clinical reference information, providing users with more informed treatment decisions at the point of care. Cvvhd removes solutes including drugs via diffusion. Types of iv compatibility many studies on the compatibility of parenteral admixtures have used precipitation, effervescence, color change, and related visual methods as the criteria for deciding if a combination is compatible. Feb 06, 2020 cover the iv bag during your infusion to protect the medicine from light. Do not mix micafungin with any other medicines, or give other medicines through the same iv line. Micafungin versus anidulafungin in critically ill patients. Iv compatibility tool available online and in our mobile software packages, this tool helps you avoid adverse events encountered in dispensing iv preparations, and maximize productivity in iv administration. Stability and compatibility of antimicrobial lock solutions. Iv doses should be expressed in milligrams not ampules, concentration or volume.
Find patient medical information for micafungin intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Micafungin for the treatment of invasive aspergillosis. In addition to updating drug interactions, precautions, alerts, and patient teaching. This iv drug compatibility chart is provided as a quick reference, however since information is subject to change it is advised that you check with a pharmacist for recommendations as well as product information to check for any changes or additional incompatibilities. Compatibility of micafungin injection with other drugs. Critical care admixtures wall chart list of iv drugs. Maintenance2575 mcgkgmin infusion or incremental bolusesof1020mg. Drug interactions are limited as the drug is not metabolized by the p450 system. Micafungin injection is used to help the body overcome serious fungus infections, such as candidemia, acute disseminated candidiasis, candida peritonitis and abscess without meningoencephalitis or ocular dissemination, and esophageal candidiasis. Check tubing below ysite carefully for discoloration, cloudiness or precipitation blank do not mix. The objective of this study was to evaluate the physical compatibility of micafungin injection with selected other drugs during simulated ysite coadministration.
Mycamine must be given slowly through an iv infusion, and each injection can take at least 1 hour to complete. You can publish your book online for free in a few minutes. Mycamine is a sterile, lyophilized product for intravenous iv infusion that contains micafungin sodium. Mycamine micafungin dosing, indications, interactions. Micafungin sodium reference guide for safe and effective use from the american society of healthsystem pharmacists ahfs di. Treatment success with micafungin has ranged from 73% to 83%, and efficacy has been comparable to liposomal amphotericin b. The essential information you need to safely administer more than 400 intravenous drugs. Trissel, begin by typing the desired drug or solution name into the appropriate search box. Micafungin must be given slowly through an iv infusion, and each injection can take at least 1 hour to complete. What conditions does micafungin solution, reconstituted. Intravenous compatibility chart acyclovir acyclovir.
Compatibility depends upon many factors including temperature, ph, iv fluid, concentration, order of mixing and brand of drug. It inhibits the production of beta1,3glucan, an essential component of fungal cell walls. Reconstitute mycamine vials by aseptically adding 5 ml of one of the following compatible solutions. Data are not available regarding the presence of micafungin in human milk, effects on breastfed infants, or effects on milk production. When a patient is initiated on crrt, antimicrobial therapy often requires adjustment to ensure adequate drug concentrations are achieved. Mycamine is a sterile, lyophilized product for intravenous iv infusion that contains. The objective of this study was to evaluate the physical compatibility of micafungin injection with selected other drugs during simulated ysite co. Micafungin inhibits the synthesis of 1, 3betadglucan, an integral component. Detailed listing of the iv drug compatibility and stability updates applied to the. A handbook for nurses and health professionals has been a trusted resource for comprehensive drug coverage, unparalleled accuracy, and an intuitive quickaccess format.
Mycamine 50mg and 100mg powder for concentrate for solution. Micafungin definition of micafungin by medical dictionary. Treatment of oesophageal candidiasis in patients for whom intravenous therapy is appropriate. To view other topics, please sign in or purchase a subscription. Baxter healthcare corporation, deerfield, illinois, yielding a 10mgml solution. Intravenous compatibility chart free html5 flip book.
Intravenous medicine administration is the administration of sterile preparations of medicines directly into a vein, via a peripheral or central line, for. Micafungin was present in the milk of lactating rats following iv administration. Mycamine 50mg and 100mg powder for concentrate for. The 2019 edition contains over 300 drug monographs, over 100 clinical updates and many new drugs. Micafungin is a topic covered in the johns hopkins abx guide to view the entire topic, please sign in or purchase a subscription official website of the johns hopkins antibiotic abx, hiv, diabetes, and psychiatry guides, powered by unbound medicine. Do not mix mycamine with any other medicines, or give other medicines through the same iv line. Compatibility of micafungin injection with other drugs during simulated ysite coadministration.
Micafungin sodium is a semisynthetic lipopeptide echinocandin synthesized by a chemical modification of a fermentation product of coleophoma empetri f11899. Micafungin sodium administration to pregnant rabbits intravenous dosing on days 6 to. The paediatric injectable guidelines 2019 edition is available as a fully laminated, spiral bound flip book, making it suitable for wet conditions such as drug preparation areas and as an online subscription. E5280, 2017, 352 pages get the support you need to safely extend dating of parenteral drugs beyond the usual 24hour limitminimizing waste, lowering medication costs, and enabling optimal patient administration schedules at alternate infusion sites. This can be accomplished by building an iv compatibility profile for one drug, or by deselecting all but one drug from a compatibility results screen and clicking the update button. Sign up for a trial of any pepid suite, including the professional nursing suite, and access it online via pepid connect to use the updated iv compatibility checker. Mycamine micafungin is an antifungal medication that fights infections caused by fungus. Nov 09, 2018 micafungin must be given slowly through an iv infusion, and each injection can take at least 1 hour to complete. Mycamine is for use in adults and children who are at least 4 months old. Micafungin side effects, dosage, interactions drugs. Mycamine is used to treat infections caused by the candida fungus.
Full text monographs for most every injectable drug available are reported in the complete king guide to parenteral admixtures. Click on trissels iv compatibility to open the module. Mycamine is for use in adults and pediatric patients. Treat for at least 14 days after resolution of symptoms or last positive culture, whichever is longer, for candidemia without metastatic complications. Physical stability was assessed by both visual observation and turbidity measurement. Visual compatibility of micafungin sodium and levofloxacin injections. The overall safety of mycamine was assessed in 3227 adult and pediatric patients and 520 volunteers in 46 clinical trials, including the invasive candidiasis, esophageal candidiasis and prophylaxis trials, who received single or multiple doses of mycamine, ranging from 0. Trissel, fashp, 2010, american society of healthsystem pharmacists. Micafungin and levofloxacin are often used in combination as part of broadspectrum empirical. Micafungin is well tolerated, with a sideeffect profile similar to that of caspofungin. Iv drug storage, compatibility, and administration. Prophylaxis of candida infections during hematopoetic stem cell transplantation. If a child is using this medication, tell your doctor if the child has any changes in weight. Iv geriatric patients, debilitated patients, or asa iiiiv patients.
Currently, there is no physical compatibility data available for micafungin dosing via a ysitecvc with sodium bicarbonate. Compatibility in common solutions and with tpntna therapies is only available when a single drug is selected for consideration. Reconstitute mycamine vials by aseptically adding 5 ml of one of the following compatible. Side effects of mycamine micafungin sodium, warnings, uses. The overall response rate of micafungin is comparable to that of anidulafungin. Stability and compatibility of antimicrobial lock solutions p. Renal dose adjustment guidelines for antimicrobials crrt. Trusley craig, kupiec thomas c, trissel lawrence a issue. Mycamine is a sterile, lyophilized product for intravenous iv infusion that. Iv drug storage, compatibility, and administration 1016.
Clin infect dis 2007 oct 1 cure rates were similar for micafungin at 100 or 150 mg per day and caspofungin at a standard dose 70 mg, then 50 mg daily. The chemical stability of micafungin in an alkaline ph aqueous solution has been reported in 2 forced degradation studies as part of the validation for stability indicating assays. Each singleuse vial contains 50 mg or 100 mg micafungin sodium, 200 mg. Dglucan, an integral component of the fungal cell wall. Identify issues surrounding stability and compatibility of iv therapies. Micafungin package insert download here free healthcaremagic app to ask a doctor all the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. Antifungal about this pubmed health uses uses of this medicine. Compatibility of micafungin injection with other drugs during. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Micafungin should be administered for at least one week after. Compare prices, print coupons and get savings tips for mycamine micafungin and other candidiasis and thrush drugs at cvs, walgreens, and other pharmacies. Admixture and syringe compatibility can be accessed from the tab of the same name.
Epinephrine, hydrocortisone, isoproterenol, lidocaine, micafungin, multiple vitamin infusion, potassium. Do not mix micafungin with any other medicines, or. Micafungin has been shown to be metabolised to several compounds. Jan 20, 2020 mycamine micafungin is an antifungal medication that fights infections caused by fungus. An enhanced iv compatibility checker that provides additional solution compatibility information is now available in pepid connect.
Our retrospective data, concerning the safety and efficacy of micafungin are in line with a recent performed study, which evaluated the safety and efficacy of micafungin monotherapy in critically ill patients with cancer and invasive candidiasis. How do you know if a combination of drugs are compatible. A number of groups, mostly from japan, have carried out clinical studies investigating the efficacy of micafungin in the treatment of aspergillus infections in a variety of clinical settings. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Possible drugsolution selections will be displayed as you continue to type. Iv drug compatibility chart the iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. Iv geriatric patients, debilitated patients, or asa iii iv patients. Micafungin package insert doctor answers on healthcaremagic. Do not tube list for pharmaceuticals revised july 2015. Appropriate studies performed to date have not demonstrated pediatricspecific problems that would limit the usefulness of micafungin injection to treat candidemia, acute disseminated candidiasis, candida peritonitis and abscess, esophageal candidiasis, and prevent candida infections with stem cell treatment in children 4 months of age and older.
Patients who receive micafungin infusion may be receiving many other parenteral drugs via ysite coadministration, including anti infectives, antiemetics. However, this study was designed to determine physical compatibility of micafungin in a basic vehicle to alkalinize the urine in patients taking concomitant hdmtx. Hjelm, pharmd, bcps, bcnsp, cgp clinical pharmacist pharmastar pbm 2. If there is an inadequate clinical response after 5 days, may increase dose to 4 mgkgday. Incompatibilities are based on meeting any of the following criteria. Do not mix micafungin with any other medicines, or give other medicines through the. Expensive intravenous medications ivs august 2016 this list includes any medication dispensed a minimum of 10 times during the preceding quarter with an average cost per. Demonstrate the safe handling of equipment used in iv therapy, e. Drug name compatibility incompatibile with abciximab. Mayjun 2006 hormone replacement therapy view all articles in issue. We selected 55 injectable drugs analyzed individually with two types of parenteral nutrition. Based on the limited data, an echinocandin drug eg, anidulafungin, caspofungin, micafungin is recommended by the cdc as initial therapy for treatment of c auris infections in adults and children aged.