Drug interactions are limited as the drug is not metabolized by the p450 system. Each singleuse vial contains 50 mg or 100 mg micafungin sodium, 200 mg. Treatment success with micafungin has ranged from 73% to 83%, and efficacy has been comparable to liposomal amphotericin b. Mycamine micafungin is an antifungal medication that fights infections caused by fungus. Mycamine must be given slowly through an iv infusion, and each injection can take at least 1 hour to complete. Iv geriatric patients, debilitated patients, or asa iii iv patients.
Micafungin is a topic covered in the johns hopkins abx guide to view the entire topic, please sign in or purchase a subscription official website of the johns hopkins antibiotic abx, hiv, diabetes, and psychiatry guides, powered by unbound medicine. Mycamine is for use in adults and children who are at least 4 months old. Micafungin versus anidulafungin in critically ill patients. Patients who receive micafungin infusion may be receiving many other parenteral drugs via ysite coadministration, including anti infectives, antiemetics. Find patient medical information for micafungin intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Micafungin intravenous route description and brand names. Iv drug storage, compatibility, and administration 1016. Mycamine is a sterile, lyophilized product for intravenous iv infusion that. Physical stability was assessed by both visual observation and turbidity measurement. The objective of this study was to evaluate the physical compatibility of micafungin injection with selected other drugs during simulated ysite coadministration.
Check tubing below ysite carefully for discoloration, cloudiness or precipitation blank do not mix. The chemical stability of micafungin in an alkaline ph aqueous solution has been reported in 2 forced degradation studies as part of the validation for stability indicating assays. Also prevents candida infection in people undergoing stem cell transplant. Micafungin sodium is a semisynthetic lipopeptide echinocandin synthesized by a chemical modification of a fermentation product of coleophoma empetri f11899. Prior to administration, have second practitioner independently check. Our retrospective data, concerning the safety and efficacy of micafungin are in line with a recent performed study, which evaluated the safety and efficacy of micafungin monotherapy in critically ill patients with cancer and invasive candidiasis. Treat for at least 14 days after resolution of symptoms or last positive culture, whichever is longer, for candidemia without metastatic complications. Micafungin has been shown to be metabolised to several compounds.
Micafungin sodium is a semisynthetic lipopeptide 12 echinocandin synthesized by a chemical modification of a fermentation product of coleophoma empetri f11899. Do not mix micafungin with any other medicines, or give other medicines through the. Iv compatibility ysite information is displayed on the first page of the search results. Midazolam versed yes midazolam versed yes midazolam versed. Micafungin intravenous route before using mayo clinic. Epinephrine, hydrocortisone, isoproterenol, lidocaine, micafungin, multiple vitamin infusion, potassium. Compatibility of micafungin injection with other drugs during. How do you know if a combination of drugs are compatible. Nov 09, 2018 micafungin must be given slowly through an iv infusion, and each injection can take at least 1 hour to complete. Intravenous compatibility chart acyclovir acyclovir. Dglucan, an integral component of the fungal cell wall.
The overall response rate of micafungin is comparable to that of anidulafungin. Mycamine micafungin for injection, for intravenous use. Trusley craig, kupiec thomas c, trissel lawrence a, year. The objective of this study was to evaluate the physical compatibility of micafungin injection with selected other drugs during simulated ysite co. Mycamine 50mg and 100mg powder for concentrate for solution. Antifungal about this pubmed health uses uses of this medicine. Unchanged micafungin is the principal circulating compound in systemic circulation. A number of groups, mostly from japan, have carried out clinical studies investigating the efficacy of micafungin in the treatment of aspergillus infections in a variety of clinical settings. This iv drug compatibility chart is provided as a quick reference, however since information is subject to change it is advised that you check with a pharmacist for recommendations as well as product information to check for any changes or additional incompatibilities. Hjelm, pharmd, bcps, bcnsp, cgp clinical pharmacist pharmastar pbm 2.
What conditions does micafungin solution, reconstituted. Intravenous medicine administration is the administration of sterile preparations of medicines directly into a vein, via a peripheral or central line, for therapeutic reasons 2007. Sign up for a trial of any pepid suite, including the professional nursing suite, and access it online via pepid connect to use the updated iv compatibility checker. Intravenous medicine administration is the administration of sterile preparations of medicines directly into a vein, via a peripheral or central line, for. Iv drug compatibility chart the iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. The following is the list of drugs found on the king guide to parenteral admixtures critical care admixtures wall chart. Cvvhd removes solutes including drugs via diffusion. Micafungin mycamine, astellas is metabolized in the liver and excreted in an inactive form in the bile and urine. Mycamine micafungin dosing, indications, interactions.
A handbook for nurses and health professionals has been a trusted resource for comprehensive drug coverage, unparalleled accuracy, and an intuitive quickaccess format. Reconstitute mycamine vials by aseptically adding 5 ml of one of the following compatible. Baxter healthcare corporation, deerfield, illinois, yielding a 10mgml solution. Maintenance2575 mcgkgmin infusion or incremental bolusesof1020mg. Incompatibilities are based on meeting any of the following criteria.
If you are taking this medicine to treat an infection, tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. If there is an inadequate clinical response after 5 days, may increase dose to 4 mgkgday. Do not mix micafungin with any other medicines, or give other medicines through the same iv line. The essential information you need to safely administer more than 400 intravenous drugs. Stability and compatibility of antimicrobial lock solutions p. Renal dose adjustment guidelines for antimicrobials crrt. The efficacy of micafungin in the treatment of invasive aspergillosis ia has not yet been evaluated in randomised, controlled studies. Demonstrate the safe handling of equipment used in iv therapy, e. Trusley craig, kupiec thomas c, trissel lawrence a issue. Mycamine is used to treat infections caused by the candida fungus. Mycamine is a sterile, lyophilized product for intravenous iv infusion that contains micafungin sodium. Micafungin sodium administration to pregnant rabbits intravenous dosing on days 6 to. A savings club is a program with a required monthly or annual fee that gives you access to special pricing. Mycamine is a sterile, lyophilized product for intravenous iv infusion that contains.
Feb 06, 2020 cover the iv bag during your infusion to protect the medicine from light. Admixture and syringe compatibility can be accessed from the tab of the same name. Detailed listing of the iv drug compatibility and stability updates applied to the king guide to parenteral admixtures over the last 12 years. Iv compatibility tool available online and in our mobile software packages, this tool helps you avoid adverse events encountered in dispensing iv preparations, and maximize productivity in iv administration. Visual compatibility of micafungin sodium and levofloxacin injections.
Trissel, fashp, 2010, american society of healthsystem pharmacists. Do not mix micafungin with any other medicines, or. Compatibility of micafungin injection with other drugs. Compatibility depends upon many factors including temperature, ph, iv fluid, concentration, order of mixing and brand of drug. Do not mix mycamine with any other medicines, or give other medicines through the same iv line. Clin infect dis 2007 oct 1 cure rates were similar for micafungin at 100 or 150 mg per day and caspofungin at a standard dose 70 mg, then 50 mg daily. You can publish your book online for free in a few minutes. However, this study was designed to determine physical compatibility of micafungin in a basic vehicle to alkalinize the urine in patients taking concomitant hdmtx. Possible drugsolution selections will be displayed as you continue to type. Iv drug storage, compatibility, and administration. Appropriate studies performed to date have not demonstrated pediatricspecific problems that would limit the usefulness of micafungin injection to treat candidemia, acute disseminated candidiasis, candida peritonitis and abscess, esophageal candidiasis, and prevent candida infections with stem cell treatment in children 4 months of age and older. Mycamine 50mg and 100mg powder for concentrate for. There are currently no randomised studies comparing micafungin with standard antifungal therapy.
Micafungin side effects, dosage, interactions drugs. Detailed listing of the iv drug compatibility and stability updates applied to the. When a patient is initiated on crrt, antimicrobial therapy often requires adjustment to ensure adequate drug concentrations are achieved. Ibm micromedex iv compatibility is a reliable resource for onthego access to the industrys most trusted clinical reference information, providing users with more informed treatment decisions at the point of care. Candidemiaacute disseminated candidiasiscandidal peritonitis and abscesses. Expensive intravenous medications ivs august 2016 this list includes any medication dispensed a minimum of 10 times during the preceding quarter with an average cost per. Types of iv compatibility many studies on the compatibility of parenteral admixtures have used precipitation, effervescence, color change, and related visual methods as the criteria for deciding if a combination is compatible.
To view other topics, please sign in or purchase a subscription. Micafungin and levofloxacin are often used in combination as part of broadspectrum empirical. Micafungin inhibits the synthesis of 1, 3betadglucan, an integral component. Full text monographs for most every injectable drug available are reported in the complete king guide to parenteral admixtures. An enhanced iv compatibility checker that provides additional solution compatibility information is now available in pepid connect. The overall safety of mycamine was assessed in 3227 adult and pediatric patients and 520 volunteers in 46 clinical trials, including the invasive candidiasis, esophageal candidiasis and prophylaxis trials, who received single or multiple doses of mycamine, ranging from 0. In addition to updating drug interactions, precautions, alerts, and patient teaching. Do not tube list for pharmaceuticals revised july 2015. To search compatibility information from the trissels 2 clinical pharmaceutics database by lawrence a. Compare prices, print coupons and get savings tips for mycamine micafungin and other candidiasis and thrush drugs at cvs, walgreens, and other pharmacies. Jan 20, 2020 mycamine micafungin is an antifungal medication that fights infections caused by fungus. Iv doses should be expressed in milligrams not ampules, concentration or volume. Iv geriatric patients, debilitated patients, or asa iiiiv patients.
The 2019 edition contains over 300 drug monographs, over 100 clinical updates and many new drugs. Compatibility in common solutions and with tpntna therapies is only available when a single drug is selected for consideration. This can be accomplished by building an iv compatibility profile for one drug, or by deselecting all but one drug from a compatibility results screen and clicking the update button. Micafungin package insert download here free healthcaremagic app to ask a doctor all the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. It is also used to prevent candida fungal infections in stem cell transplant patients. Currently, there is no physical compatibility data available for micafungin dosing via a ysitecvc with sodium bicarbonate. Prophylaxis of candida infections during hematopoetic stem cell transplantation. If a child is using this medication, tell your doctor if the child has any changes in weight. Side effects of mycamine micafungin sodium, warnings, uses. Renal dose adjustment guidelines for antimicrobials. Sirolimus and nifedipine levels are increased by 20%.
E5280, 2017, 352 pages get the support you need to safely extend dating of parenteral drugs beyond the usual 24hour limitminimizing waste, lowering medication costs, and enabling optimal patient administration schedules at alternate infusion sites. Mycamine is for use in adults and pediatric patients. Treatment of candidemia, acute disseminated candidiasis, candida peritonitis and abscesses without. Critical care admixtures wall chart list of iv drugs. Micafungin sodium reference guide for safe and effective use from the american society of healthsystem pharmacists ahfs di. Based on the limited data, an echinocandin drug eg, anidulafungin, caspofungin, micafungin is recommended by the cdc as initial therapy for treatment of c auris infections in adults and children aged. Micafungin definition of micafungin by medical dictionary. Mayjun 2006 hormone replacement therapy view all articles in issue.
Safety and pharmacokinetics of repeatdose micafungin in. Jan, 2020 mycamine micafungin sodium for intravenous infusion. Identify issues surrounding stability and compatibility of iv therapies. Micafungin trade name mycamine is an echinocandin antifungal drug used to treat and prevent invasive fungal infections including candidemia, abscesses and esophageal candidiasis. Trissel, begin by typing the desired drug or solution name into the appropriate search box. Compatibility of micafungin injection with other drugs during simulated ysite coadministration. Micafungin was present in the milk of lactating rats following iv administration. Micafungin is a semisynthetic echinocandin derived from a natural product of the fungus coleophama empedri with potent antifungal activity. Micafungin, like other cyclic lipopeptides, noncompetitively inhibits the fungal specific enzyme 1,3betadglucan synthase, an enzyme essential for fungal cell wall synthesis. Drug name compatibility incompatibile with abciximab.
Micafungin for the treatment of invasive aspergillosis. Micafungin package insert doctor answers on healthcaremagic. Data are not available regarding the presence of micafungin in human milk, effects on breastfed infants, or effects on milk production. Stability and compatibility of antimicrobial lock solutions.
Micafungin should be administered for at least one week after. Micafungin must be given slowly through an iv infusion, and each injection can take at least 1 hour to complete. Micafungin is well tolerated, with a sideeffect profile similar to that of caspofungin. What conditions does micafungin solution, reconstituted recon soln treat. Treatment of candidemia, acute disseminated candidiasis, candida peritonitis and abscesses in adult and pediatric patients 4 months of age and older see clinical studies 14. Intravenous compatibility chart free html5 flip book. Click on trissels iv compatibility to open the module. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Treatment of oesophageal candidiasis in patients for whom intravenous therapy is appropriate. We selected 55 injectable drugs analyzed individually with two types of parenteral nutrition. Learn vocabulary, terms, and more with flashcards, games, and other study tools. The paediatric injectable guidelines 2019 edition is available as a fully laminated, spiral bound flip book, making it suitable for wet conditions such as drug preparation areas and as an online subscription.